Plinest®
Polynucleotides are advanced regenerative injectables made from highly purified fragments of DNA. In aesthetic medicine, they are used to repair, regenerate, and improve skin quality at a cellular level rather than simply adding volume.
These naturally derived molecules act as biostimulators, encouraging the skin to heal, renew, and function more like younger, healthier tissue.
How it works
Working beneath the surface, polynucleotides encourage your skin to repair, regenerate and renew itself naturally.
1
Stimulates
Stimulate collagen and elastin production to improve skin firmness and elasticity
2
Supports
Support tissue repair by encouraging the skin’s natural regeneration process.
3
Boosts
Boost hydration to enhance skin quality and radiance.
4
Strengthens
Strengthen and restore the skin for smoother, healthier-looking skin over time.
At a glance
Treatment Time
20-30 minutes
Sessions
3-4 sessions
Frequency
2-4 weeks
Results Visable
1-2 weeks
Longevity
6-9 months
Price
Polynucleotides FAQs
What is Plinest®?
Plinest® is a leading polynucleotide-based injectable treatment that uses a patented purification process (PN-HPT®) to deliver ultra-pure DNA fragments into the skin.
It is designed to:
• Regenerate damaged skin
• Stimulate collagen and elastin production
• Improve hydration and elasticity
• Restore overall skin health
Unlike dermal fillers, Plinest® focuses on skin regeneration rather than volume enhancement, giving subtle, natural-looking results.
How Do Plinest Polynucleotides Work?
Once injected into the skin, polynucleotides act as biological messengers, activating the skin’s natural repair processes.
They work by:
• Stimulating fibroblasts (cells responsible for collagen and elastin)
• Promoting tissue repair and regeneration
• Increasing hydration by binding water within the skin
• Improving microcirculation and nutrient supply
• Reducing inflammation and oxidative stress
This results in stronger, healthier, and more resilient skin over time.
Key Benefits of Plinest®
• Improves skin texture and elasticity
• Stimulates collagen and elastin production
• Deeply hydrates and revitalises the skin
• Softens fine lines and wrinkles
• Reduces dark circles and pigmentation
• Helps with acne scarring and rosacea
• Strengthens and repairs damaged skin
• Provides natural, subtle rejuvenation
Treatment Areas
Plinest® is highly versatile and can be used on:
• Face
• Under-eye area (Plinest® Eyes)
• Neck
• Décolletage
• Hands
• Scalp (for hair thinning)
Who is it Suitable For?
Polynucleotides are ideal for clients who:
• Want natural skin rejuvenation without filler
• Have fine lines, wrinkles, or loss of elasticity
• Experience dull, dehydrated, or crepey skin
• Are concerned about dark circles or under-eye ageing
• Have acne scarring or uneven skin texture
• Want to improve scalp health or hair thinning
Suitable for most skin types and ages, including those looking for preventative treatments.
Treatment Protocol
• Course of 3–4 sessions
• Spaced 2–4 weeks apart
• Treatment time: 20–30 minutes
• Maintenance every 6–9 months
Results
Results develop gradually as the skin regenerates:
• Improved hydration and glow within 1–2 weeks
• Progressive collagen stimulation over several weeks
• Skin appears firmer, smoother, and more radiant
• Long-lasting improvement in overall skin quality
Clinical data suggests improvements in elasticity, hydration, and visible skin quality following treatment.
Downtime & Aftercare
Plinest® is a minimally invasive treatment with little downtime.
You may experience:
• Mild redness or swelling
• Small injection bumps
• Occasional bruising
These typically resolve within 24–48 hours.
Noa Medical Aesthetics 